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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro anddownstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cellproliferation, colony formation inhibition, and cell cycle arrest.For the first time, this study reveals that RFC4 is required for NPC cell proliferation and may play

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cellproliferation and

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cellproliferation in vitro and in vivo

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cellResults showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cellproliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P&

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCWe previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymaticALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelialFurthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2

Keywords： ALDOB     kidney cancer     cell proliferation    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: The aim of this study was to investigate the role of pirh2 (p53-induced RING-H2) protein in the proliferation, apoptosis and cell cycle control of the lung cancer cell line A549.Cell proliferation was assessed by cell counting kit-8 (CCK-8).The inhibition of pirh2 expression by siRNA (psiRNA-pirh2) resulted in reduced cell proliferation andin reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis and

Keywords： control     interruption     cytoplasm     number     growth    

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: interference approaches revealed that the loss of GNAQ/11 palmitoylation substantially affected tumor cellproliferation and survival in UM cells.Importantly, the palmitoylation-deficient oncogenic GNAQ/11 failed to rescue the cell death initiatedoncogenes in UM cells, which are much more dependent on Gαq/11 signaling for cellsurvival and proliferation than other melanoma cells without GNAQ/11 mutations.

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 374-379 doi: 10.1007/s11684-008-0072-4

Abstract: Proliferation and apoptosis were assayed by MTT and flow cytometry with Annexin-V-FITC/PI staining.expression of gene DNMT1 mRNA and protein effectively, and to some extent, it also can inhibit the proliferationof bladder cancer cell and promote the cellular apoptosis.
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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 91-100 doi: 10.1007/s11684-020-0778-5

Abstract: Knockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells andthese results suggest that lncRNA SAP30-2:1 may be involved in heart development through affecting cellproliferation via targeting HAND2 and may thus represent a novel therapeutic target for CHD.

Keywords： congenital heart disease     Gene Expression Omnibus     lncRNA SAP30-2:1     cell proliferation     RNA immunoprecipitation    

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Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 379-383 doi: 10.1007/s11684-009-0073-y

Abstract: p38 regulated/activated protein kinase (PRAK) plays a key role in cell senescence and tumor suppressionThe aim of this study was to investigate if PRAK had effect on cell proliferation.cells was measured by methylthiazoletetrazolium (MTT) colorimetric assay, and the proportion of the cellnumber in different phases of the cell cycle was analyzed by flow cytometry.Taken together, gene knockout in MEF cells leads to cell cycle arrest and proliferation inhibition.

Keywords： p38 regulated/activated protein kinase     gene knockout     cell cycle     cell proliferation    

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Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing

Xiaodong Duan, Daizhi Peng, Yilan Zhang, Yalan Huang, Xiao Liu, Ruifu Li, Xin Zhou, Jing Liu

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 289-300 doi: 10.1007/s11684-017-0550-7

Abstract: treating HaCaT cells with Ag+and/or the active oxygen scavenger N-acetyl cysteine (NAC), cellIn addition, 5-bromo-2-deoxyUridine (BrdU) incorporation assays, cell cycle flow cytometry, and proliferatingcell nuclear antigen (PCNA) immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic/sup>, with 10−5 mol/L Ag+ markedly increasing the cellproliferation index.

Keywords： ionic silver     human keratinocyte     cell proliferation     reactive oxygen species     active oxygen scavenger     NAC    

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NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Reactive oxygen species (ROS) are small molecule metabolites of oxygen that are prone to participate in redox reactions their high reactivity. Intracellular ROS could be generated in reduced nicotinamide-adenine dinucleotidephosphate (NADPH) oxidase-dependent and/or NADPH oxidase-independent manners. Physiologically, ROS are involved in many signaling cascades that contribute to normal processes. One classical example is that ROS derived from the NADPH oxidase and released in neurotrophils are able to digest invading bacteria. Excessive ROS, however, contribute to pathogenesis of various human diseases including cancer, aging, dimentia and hypertension. As signaling messengers, ROS are able to oxidize many targets such as DNA, proteins and lipids, which may be linked with tumor growth, invasion or metastasis. The present review summarizes recent advances in our comprehensive understanding of ROS-linked signaling pathways in regulation of tumor growth, invasion and metastasis, and focuses on the role of the NADPH oxidase-derived ROS in cancer pathogenesis.

Keywords： free radicals     tumor     phox     cell proliferation     cancer therapy    

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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract:

Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of componentsinvolved in the cell cycle machinery.that PML/RARα directly bound to the CDKN2C promoter in the APL patient-derived cellFunctional studies showed that ectopic expression of CDKN2C induced a cell cycle arrest at the GCollectively, this study highlights the importance of CDKN2C inactivation in the abnormal cell cycle

Keywords： CDKN2C     acute promyelocytic leukemia     cell cycle arrest     differentiation    

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Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancer cells, but the underneath rationale has remained to be elucidated. Based on the concept of the degree of reduction of a compound, we have recently proposed a calculation termed as potential of electron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolic transformations. When this calculation is combined with the assumed model of electron balance in a cellular context, the enforced selective reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolism. Some interesting properties of PET in cancer cells were also discussed, and the model was extended to uncover the chemical nature underlying aerobic glycolysis that essentially results from energy requirement and electron balance. Enabling electron transfer could drive metabolic reprogramming in cancer metabolism. Therefore, the concept and model established on electron transfer could guide the treatment strategies of tumors and future studies on cellular metabolism.

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferationResults of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emission

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter     radiation therapy     proliferation    

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract: level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell

Keywords： network     transcription     cancer     MYC     MAX     MLX    

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Title Author Date Type Operation

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cellproliferation and

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cellproliferation in vitro and in vivo

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Journal Article

Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Journal Article

Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Journal Article

Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing

Xiaodong Duan, Daizhi Peng, Yilan Zhang, Yalan Huang, Xiao Liu, Ruifu Li, Xin Zhou, Jing Liu

Journal Article

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Journal Article

Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Journal Article